Purposeful synthesis of new antiviral active substances

Model of the deactivated HIV Protease, an essential enzyme of the HIV (openPR) - endotherm and PharmaInformatic cooperate during the development and optimization of medicines against infections

Saarbruecken/Emden, 12 December 2006 - which has enterprise endotherm GmbH and PharmaInformatic today a co-operation within the range of the development and optimization of antiviral active substances agrees. In the context of this co-operation prognosticates PharmaInformatic, in chemistry computer science specialized an enterprise, by expert systems the antiviral and pharmakokinetischen characteristics of substances at the computer. Suitable candidates for an advancement to the medicine are identified and manufactured by endotherm by means of chemical synthesis purposefully.

Development costs for a new medicine on the average 900 millions US-$ amount to, whereby the entire process can take more than 12 years. Here a majority of the research costs is spent on substances, which due to insufficient ADME/Tox characteristics (from the English for admission, distribution, amplifier off changing, elimination and toxicity of substances in the body) at the market to never arrive.

The experimental determination of the ADME/Tox characteristics takes place only years after the synthesis of the active substances in clinical studies. The forecast of these substance characteristics permits a selection of the most promising active substance candidates with the best ADME/Tox characteristics, whereby the efficiency of the active substance research in an early stage is importantly increased.

PharmaInformatic
Friesenstr. 36
26721 Emden
Germany
Dr. Wolfgang Boomgaarden
04921-993360
www.pharmainformatic.com/html/contact_us.html

Endothermically GmbH
The endotherm GmbH was created in the year 1999 and offers exclusive research services and order syntheses for the production of pharmaceutical relevant substances for the early phase of the medicament development. To the customers of endotherm among other things Altana, Aventis, Bavarian, Boehringer Ingelheim, Merck, Solvay, black Bioscience, Schering and Takeda belong. Further information under: www.endotherm.de

PharmaInformatic
PharmaInformatic develops expert systems for the optimization of the active substance development. The platform technology of the enterprise contains millions of substances linked with experimental data and several thousands 3D-Modelle von Biomolekülen. Proprietäre methods of chemistry computer science and bio computer science make possible the prognosis action spectrum of a substance as well as its pharmakologische characteristics. Further information under: www.pharmainformatic.com

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OpenPR - http://openpr.de/news/112191/Gezielte-Synthese-neuer-antiviraler-Wirkstoffe.html